A member from N4G has noticed an emerging problem among the Ps3 trophy collecting community. This error only shows up when you try to play a game that supports trophies.
Booting up the game will give an error message (80022D11) followed by a message to quit your game and delete your saved file. Ps3Trophies.org was given the information that Sony will be releasing a patch to fix the problem within the next couple of weeks.
Corey, the person who actually reported the problem to N4G suggests waiting for the patch and not deleting any of your saved files. BIG thanks to Corey for finding the information!
UPDATE: Possible fix and solution can be found here.